Myostatin (GDF-8) inhibits muscle mass, and interruption of this gene has shown to result in a great deal of skeletal muscle growth. The main area in which myostatin is expressed is in skeletal muscle; inactivation of myostatin in this instance produces an increase in muscle mass in many animal species. Work using Myostatin knock-out mice – experiments where myostatin is rendered inactive – showed that these mice exhibited muscles around 2 to 3 times larger than mice which carried the normal Myostatin gene.
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